R语言已发布的TB签名的注释信息。sigAnnotData()函数-中英文对照帮助文档

MicroRbt

        R语言已发布的TB签名的注释信息。sigAnnotData()函数-中英文对照帮助文档

                                         By MicroRbt Martinez PhD

R语言函数名：sigAnnotData()
R语言函数功能：已发布的TB签名的注释信息。
来自资源库：Bionconductor-software
sigAnnotData()函数所属R语言包：所在R包具体名称、包功能的中英文双语描述见正文后面'--所在R语言包信息--'部分。

描述-----Description-----

A data.frame of annotation information for published tuberculosis signatures. Currently, this table includes two variables, disease and tissue type.
发布的结核病签名的注释信息的数据框。当前，该表包括两个变量，disease和tissue type。


使用方法-----Usage-----

sigAnnotData

-----Format-----

data.frame
数据框架


详情-----Details-----

The disease variable indicates whether the signature was developed to distinguish TB from LTBI ("Disease"), TB from some combination of other diseases and possibly LTBI ("OD"), TB from Human Immunodeficiency Virus ("HIV"), TB from pneumonia ("PNA"), or identify risk of progression to TB ("RISK"), risk of TB treatment failure ("FAIL"), or classify treatment responses (i.e., failures from cures, "RES").
disease变量指示是否开发了签名以区分TB与LTBI（“疾病”），TB与其他疾病的组合以及可能与LTBI（“ OD”），TB与人免疫缺陷病毒（“ HIV”），TB与肺炎（“ PNA”），或确定发展为结核病的风险（“风险”），结核病治疗失败的风险（“失败”），或对治疗反应进行分类（即，治愈失败，“ RES”）。

The tissue type variable denotes whether the signature was developed using samples of either whole blood/paxgene or peripheral blood mononuclear cells (PBMCs). Due to the manipulation of cells inherently required to obtain PBMCs, many scientists prefer to use only whole blood samples for analysis.
tissue type变量表示签名是使用全血/ paxgene还是外周血单核细胞（PBMC）的样品开发的。由于获得PBMC固有地需要操纵细胞，因此许多科学家更喜欢仅使用全血样品进行分析。


-----Source-----

<ul>
参数Anderson_42介绍: Anderson, Suzanne T., Myrsini Kaforou, Andrew J. Brent, Victoria J. Wright, Claire M. Banwell, George Chagaluka, Amelia C. Crampin, et al. 2014. "Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa." The New England Journal of Medicine 370 (18): 1712-23. 10.1056/NEJMoa1303657

参数Anderson_OD_51介绍: Anderson, Suzanne T., Myrsini Kaforou, Andrew J. Brent, Victoria J. Wright, Claire M. Banwell, George Chagaluka, Amelia C. Crampin, et al. 2014. "Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa." The New England Journal of Medicine 370 (18): 1712-23. 10.1056/NEJMoa1303657

参数Berry_393介绍: Berry, Matthew P. R., Christine M. Graham, Finlay W. McNab, Zhaohui Xu, Susannah A. A. Bloch, Tolu Oni, Katalin A. Wilkinson, et al. 2010. "An Interferon-Inducible Neutrophil-Driven Blood Transcriptional Signature in Human Tuberculosis." Nature 466 (7309): 973-77. 10.1038/nature09247

参数Berry_OD_86介绍: Berry, Matthew P. R., Christine M. Graham, Finlay W. McNab, Zhaohui Xu, Susannah A. A. Bloch, Tolu Oni, Katalin A. Wilkinson, et al. 2010. "An Interferon-Inducible Neutrophil-Driven Blood Transcriptional Signature in Human Tuberculosis." Nature 466 (7309): 973-77. 10.1038/nature09247

参数Blankley_5介绍: Blankley, Simon, Christine M. Graham, Joe Levin, Jacob Turner, Matthew P. R. Berry, Chloe I. Bloom, Zhaohui Xu, et al. 2016. "A 380-Gene Meta-Signature of Active Tuberculosis Compared with Healthy Controls." The European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology 47 (6): 1873-76. 10.1183/13993003.02121-2015

参数Blankley_380介绍: Blankley, Simon, Christine M. Graham, Joe Levin, Jacob Turner, Matthew P. R. Berry, Chloe I. Bloom, Zhaohui Xu, et al. 2016. "A 380-Gene Meta-Signature of Active Tuberculosis Compared with Healthy Controls." The European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology 47 (6): 1873-76. 10.1183/13993003.02121-2015

参数Bloom_OD_144介绍: Bloom, Chloe I., Christine M. Graham, Matthew P. R. Berry, Fotini Rozakeas, Paul S. Redford, Yuanyuan Wang, Zhaohui Xu, et al. 2013. "Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers." PloS One 8 (8): e70630. 10.1371/journal.pone.0070630

参数Esmail_82介绍: Esmail, Hanif, Rachel P. Lai, Maia Lesosky, Katalin A. Wilkinson, Christine M. Graham, Stuart Horswell, Anna K. Coussens, Clifton E. Barry 3rd, Anne O'Garra, and Robert J. Wilkinson. 2018. "Complement Pathway Gene Activation and Rising Circulating Immune Complexes Characterize Early Disease in HIV-Associated Tuberculosis." P

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